Scientist, Protein Purification
Company: Disability Solutions
Location: Emeryville
Posted on: October 10, 2024
Job Description:
Scientist, Protein PurificationPosition Summary:Catalent Pharma
Solutions is the leading provider of pharmaceutical development
services, drug delivery technologies, manufacturing, packaging, and
product commercialization services--to the global pharmaceutical
and biotechnology industry.-- We employ--over 19,000--people
in--more than 50 facilities--worldwide with reported--annual
revenues of approximately $4 billion. At Catalent, we take pride in
providing a shared commitment to build employee capability, and
foster a culture of inclusion, where talent and potential are
unleashed, and where employees are committed and engaged to achieve
results.Catalent Biologics Emeryville, CA site, formerly the
startup company Redwood Bioscience, has developed a proprietary
approach for site-specific bioconjugation to produce
next-generation antibody-drug conjugates (ADCs). This technology,
termed SMARTag--, is based on use of the aldehyde-tag site-specific
protein modification technology and Catalent's novel conjugation
chemistry and proprietary, stable linkers. SMARTag is a
clinical-stage technology that was named Runner Up for Best
Platform at the 2022 World ADC Awards in San Diego, CA. The
Catalent Biologics Emeryville site comprises a close-knit team of
scientists working cross-functionally with each other to nimbly
achieve our goals and milestones. We are a research site, working
to develop therapeutic ADC drug candidates for clinical testing. We
also continuously strive to improve and expand our technology
platform. The team has a focus on publishing papers and filing
intellectual property to contribute to the exciting and dynamic
field of bioconjugation and drug conjugates.Catalent Pharma
Solutions at our Emeryville, CA location is seeking a Scientist in
Protein Purification who will be responsible for the purification
and characterization of antibodies and related protein formats
(e.g., bispecifics) to support the generation of antibody-drug
conjugates using the SMARTag platform. The Scientist, Protein
Purification will be skilled in protein purification using AKTA
FPLC and other chromatography methods. --This is a full-time
position, Monday - Friday, day shift with flexible work hours. This
position is based in Emeryville, CA, 94608 in the EmeryStation West
campus, at 5959 Horton St., easily accessible by BART /
EmeryGoRound, AMTRAK, or car (with private, secured, on-site
parking provided).Catalent is committed to a Patient First culture
through excellence in quality and--compliance, and to the safety of
every patient, consumer, and Catalent employee.--The Role:
- Primary responsibility for producing and assessing the purity
and homogeneity of complex proteins such as engineered antibodies
(e.g., bispecifics, Fc-fusions, and/or bioconjugated
therapeutics)
- Conducting medium to high throughput antibody purifications
generating milligram to gram scale of antibodies for in vitro and
in vivo studies
- Through process development approaches and biophysical and
biochemical characterizations, candidate will be responsible for
optimizing methods and generating data to support and meet
timelines for production of a wide variety of antibodies including
bispecific and Fc-fusion molecules
- Development and troubleshooting of purification processes for
large molecule biotherapeutics from milligram to gram scale,
including the development of robust and scalable purification
processes
- Test antibody and ADC binding and internalization
characteristics through ELISA and flow cytometry-based methods.
Hands-on regular us of AKTA-FPLC and protein/antibody purification
downstream
- Quality assurance of proteins using HPLC, SDS-PAGE, isoelectric
focusing and other analytical techniques
- Identifying and applying new methods to improve the quality of
process and product. Share results and ideas across the site's
multi-disciplinary teams. Generate data to support strategic
partner relationships, platform development, patents, and
publications
- Maintain electronic laboratory notebook and protect
intellectual properties of the company
- Other duties as assignedThe Candidate:
- Minimum education requirement of a Bachelor's in Biology,
Chemistry, Biochemistry or a related discipline with 7+ years of
additional industry research experience required. Candidates with a
PhD and no experience or a Master's (M.S.) degree with 3+ years of
additional research experience will also be considered
- Extensive experience in antibody/protein purification with AKTA
FPLC systems using variety of chromatography methods including
affinity, ion exchange, hydrophobic interaction, size exclusion,
and others
- Must have experience with using HPLC, SDS-PAGE, CD-SDS,
isoelectric focusing, and other analytical techniques
- Familiar with biophysical techniques such as light scattering,
thermal shift assay and developability assessments
- Understanding DNA manipulations and expression of recombinant
proteins in mammalian cells using transient transfection method is
a plus
- Knowledge of biochemical assays including ELISA, Octet BLI
systems and others will be favorably considered
- Desire and ability to learn new skills to help contribute to
our multi-disciplinary teams. Candidates should have a track record
of problem solving, collaboration, data management, and strong
communication skills
- Physical Requirements: must be able to sit/stand/walk regularly
with use of computers/phones on a daily basis. Must be able to lift
up to 15lbsPay:
- The anticipated salary range for this role in California is
$115,000 to $125,000 annually. The final salary offered to a
successful candidate may vary, and will be dependent on several
factors that may include but are not limited to: the type and
length of experience within the job, type and length of experience
within the industry, skillset, education, business needs, etc.
--Catalent is a multi-state employer and this salary range may not
reflect positions that work in other states.Why you should join
Catalent:
- Awesome team collaboration with potential for career growth on
an expanding team within an organization dedicated to preserving
and bettering lives--
- Defined career path and annual performance review and feedback
process--
- Diverse, inclusive culture--with several Employee Resource
Groups focusing on D&I
- 152 hours of PTO + 8 paid holidays
- Dynamic, fast-paced work environment
- Positive working environment focusing on continually improving
processes to remain innovative
- Community engagement and green initiatives--
- Generous 401K match
- Medical, dental and vision benefits effective day one of
employment--
- Tuition Reimbursement--- Let us help you finish your degree or
earn a new one!
- WellHub program to promote overall physical wellness--
- Perkspot - offers exclusive or private discounts from
approximately 900+ merchants in a wide array of categoriesCatalent
offers rewarding opportunities to further your career!-- Join the
global drug development and delivery leader and help us bring over
7,000 life-saving and life-enhancing products to patients around
the world. Catalent is an exciting and growing international
company where employees work directly with pharma, biopharma and
consumer health companies of all sizes to advance new medicines
from early development to clinical trials and to the market.
Catalent produces more than 70 billion doses per year, and each one
will be used by someone who is counting on us. Join us in making a
difference.--personal initiative. dynamic pace. meaningful
work.Visit to explore career opportunities.Catalent is an Equal
Opportunity Employer, including disability and veterans.If you
require reasonable accommodation for any part of the application or
hiring process due to a disability, you may submit your request by
sending an email, and confirming your request for an accommodation
and include the job number, title and location to . This option is
reserved for individuals who require accommodation due to a
disability. Information received will be processed by a U.S.
Catalent employee and then routed to a local recruiter who will
provide assistance to ensure appropriate consideration in the
application or hiring process.--------Notice to Agency and Search
Firm Representatives: Catalent Pharma Solutions (Catalent) is not
accepting unsolicited resumes from agencies and/or search firms for
this job posting. Resumes submitted to any Catalent employee by a
third party agency and/or search firm without a valid written &
signed search agreement, will become the sole property of Catalent.
No fee will be paid if a candidate is hired for this position as a
result of an unsolicited agency or search firm referral. Thank
you.Important Security Notice to U.S. Job Seekers:Catalent NEVER
asks candidates to provide any type of payment, bank details,
photocopies of identification, social security number or other
highly sensitive personal information during the offer process, and
we NEVER do so via email or social media. If you receive any such
request, DO NOT respond- it is a fraudulent request. Please forward
such requests to spam@catalent.com for us to investigate with local
authorities.California Job Seekers can find our California Job
Applicant Notice .
Keywords: Disability Solutions, San Rafael , Scientist, Protein Purification, Other , Emeryville, California
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